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Testosterone Injection In Pakistan – Endogenous testosterone is responsible for sexual maturation at all stages of development throughout life. Synthetically, it is prepared from cholesterol. The function of androgens in male development begins in the fetus, is crucial during puberty, and continues to play an important role in the adult male. Women also secrete small amounts of testosterone from the ovaries. The secretion of androgens from the adrenal cortex is insufficient to maintain male sexuality.
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Increased androgen plasma concentrations suppress gonadotropin-releasing hormone (reducing endogenous testosterone), luteinizing hormone, and follicle-stimulating hormone by a negative-feedback mechanism. Testosterone also affects the formation of erythropoietin, the balance of calcium, and blood glucose. Androgens have a high lipid solubility, enabling them to rapidly enter cells of target tissues. Within the cells, testosterone undergoes enzymatic conversion to 5-alpha-dihydrotestosterone and forms a loosely bound complex with cystolic receptors. Androgen action arises from the initiation of transcription and cellular changes in the nucleus brought about by this steroid-receptor complex.
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Normally, endogenous androgens stimulate RNA polymerase, resulting in an increased protein production.These proteins are responsible for normal male sexual development, including the growth and maturation of the prostate, seminal vesicle, penis, and scrotum. During puberty, androgens cause a sudden increase in growth and development of muscle, with redistribution of body fat. Changes also take place in the larynx and vocal cords, deepening the voice. Puberty is completed with beard development and growth of body hair. Fusion of the epiphyses and termination of growth is also governed by the androgens, as is the maintenance of spermatogenesis. When endogenous androgens are unavailable, use of exogenous androgens are necessary for normal male growth and development.
Testosterone Injection Uses
- Treating hypogonadism: This is a condition where the body doesn’t produce enough testosterone. Symptoms of hypogonadism can include low libido, erectile dysfunction, fatigue, muscle loss, and bone loss. Testosterone injections can help to improve these symptoms and restore testosterone levels to a normal range.
- Gender-affirming therapy for transgender men and non-binary individuals: Testosterone injections are a key part of gender-affirming hormone therapy for transgender men and non-binary individuals who wish to develop masculine physical characteristics.
It’s important to note that testosterone injections are not appropriate for everyone and can have side effects, including:
- Increased hair growth
- Mood swings
- Liver problems
- Increased risk of blood clots
If you’re considering testosterone injections, it’s important to talk to your doctor about the risks and benefits to decide if they’re right for you.