White Kwao Krua Tablets Price In Pakistan
White Kwao Krua Tablets In Pakistan – White kwao krua is an edible plant that grows in Southeast Asia. It is very rich in natural phytoestrogens. Previous clinical studies revealed that theuse of White kwao krua as a hormone replacement therapy has beneficial effects on the lipid profile of menopause women. In this present study, weutilized the hypercholesterolemia rabbit model to demonstrate the effect of White kwao krua on the daily intake of high-fat diet.
We inducedhypercholesterolemia in rabbits by feeding with high-fat diet (1% cholesterol-containing diet). The animals were maintained 12 weeks for theexperimentation. The White kwao krua supplement was administered 100 mg/kg/day, and the effects were monitored comparing with Statins andturmeric. Blood was collected periodically to monitor the plasma cholesterol level and the oxidative susceptibility of isolated LDL-cholesterol. Attheend of the experiment, the aorta was collected from the animal and performed endothelial-dependent relaxation and endothelial-independent relaxation assays.
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The relative ratio of intima to media layer was microscopically evaluated from hematoxylin/eosin-stained tissues.We showed that the White kwao krua supplement reduced LDL-cholesterol about 40% compared with high-fat diet consumption alone. Administration of White kwao krua had significantly prolonged the susceptibility of LDL-cholesterol to oxidation. Besides, it led to the improvement of vascular function by recovering endothelium-dependent relaxation and alleviating vascular structure impairment induced by high-fat dietary intake.
Together, we suggest that White kwao krua should be used as a dietary supplement to reduce the atherogenesis in high-fat dietary consumption.Atherosclerosis is the major cause of the cardiovascular disease (CVD), the predominant cause of death worldwide. Several previous studies demonstrated that dyslipidemia, oxidation, and inflammation related to the pathogenesis of atherosclerosis.
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White Kwao Krua In Pakistan 1 The increase of plasma low-density lipoprotein (LDL) from the diet passes through the endothelial barrier and deposits on the arterial wall, plays a crucial role in atherosclerosis development. The accumulation of LDL transforms into oxidized-LDL (oxLDL) and constitutes the hallmark of the disease.
The presence of oxLDL not only produces self-reactive oxygen species (ROS) but also activates endothelial cells to release more ROS and pro-inflammatory cytokines.2 This increases the leukocyte migration, subendothelial space retention,3 leukocyte adhesion to the vascular endothelial cells,4 and even synergizes the effect of air-pollutant-induced vascular inflammation.5
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